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Niacinamide is very helpful in building cells in the skin

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Anderson K.J., Teuber S.S., Gobeille A., Cremin P., Waterhouse A.L., Steinberg F.M

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Therapeutically, the axis can be interrupted by iron chelation (e.g., deferoxamine or deferiprone, with awareness of anemia/infection risks), radical-trapping antioxidants (ferrostatin-1, liproxstatin-1), selenium supplementation or GPX4 support (restoring the glutathioneGPX4 system), limiting LIP release by restraining ferritinophagy and, context-dependently, LOX/ACSL4 modulation or reinforcement of FSP1/CoQ10 defensesalways paired with biomarker guidance (LIP assays, ferritin/NCOA4/HO-1 status, lipid-peroxide readouts) to avoid blunting physiological iron/redox signalling (Mao et al