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Historically, studies concerning hydrogen peroxide in plants focused on describing production sites, scavenging or removal mechanisms, and involvement in growth and development-related signaling pathways
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Following IV administration of 2 mg/kg in bile duct cannulated (BDC) rats, urinary and biliary excretions of unchanged parent drug were 65 and 0.8% of dose, respectively, suggesting that urinary excretion is a major elimination route for GS-441524 in rats
