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Therefore, neuroinflammation induced in depression disrupts neurotransmission and thus promotes the development of depression (Hardingham et al., 2002
Except for anti-IGF-IR or anti-IGF1/2 mAbs, many small-molecule IGF-IR inhibitors have been developed [158,159,160,161,162,163]

PubMed PMID: WOS:000165066400046
A recent study found that firefighters exposed to one such class of compounds, haloalkanes, developed gliomas with tumor signatures associated with this exposure (331)Cannataro VL, et al
