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The addition of excess Gln reversed the defective differentiation of SLC1A5 -/- T cells into Th17 cells (49)
In conclusion, while the multifaceted roles of lactate in physiology and disease are increasingly clear from preclinical work, a significant translational gap remains
64 In addition, patients who are treated with Cu-histidine in an early stage of the disease can exhibit gross improvements, with fine neuronal development and motor movement, whereas patients who are diagnosed and treated in a later stage generally have a poor prognosis
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