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The process of the removal of old erythrocytes from the circulation is also known as senescence, and similar to eryptosis, this process may be preferentially executed due to oxidative stress, hyperosmolarity, and energy depletion [24, 134]

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However, randomized controlled clinical trials have shown that high supraphysiological doses of VD are needed to achieve the required levels of VD in the circulation and that not all subjects respond to vitamin D (VD) supplementation (22, 31, 33, 51)