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Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy

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Analysis of the differentially expressed proteins determined that they belong to mitochondrial, cytoskeleton, cytoplasmic, and cytoskeleton organizing proteins (168)