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"Is this product safe" is a hard question for any clinician to answer definitively given the same evidence gap described above, but a few specific, answerable questions tend to be more useful in that conversation: These are the clearest reasons a clinician might specifically advise against any additional copper exposure, topical or otherwise, regardless of pregnancy status

That said, even with triple the vitamin B12 intake, pregnant mothers serum vitamin B12 dipped into the low-to-mid range of normal in this study

Specific Dosage Guidelines Severe Deficiency : For patients with severe vitamin B12 deficiency, an initial dose of 1 mg (1000 g) of intramuscular hydroxocobalamin is commonly administered

The addition of the AHK-Cu complex may potentially have stimulated the proliferation of normal dermal fibroblasts and possibly enhanced their viability