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Although these results should be confirmed by a large, randomized, experiment to validate a possible therapeutic role, considering the low cost and the good safety profile, L-carnitine therapy could be now deemed as a possible treatment in selected, high-risk patients

Another mechanism may involve activation of sirtuins, especially sirtuin1 (SIRT1) and its transcriptional co-factor peroxisome proliferator-activated receptor- coactivator 1 alpha (PGC-1), although few data of human studies are available 26

Pressure and fit can be adjusted with the turn screw that stays adjusted for repetitive use