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The co-localization of GSTP and HMGB1 in the nucleus was confirmed by the confocal microscopy (Figure 4E)
Signaling Mechanisms of Nuclear Factor-B-Mediated Activation of Inflammatory Genes by 13-Hydroperoxyoctadecadienoic Acid in Cultured Vascular Smooth Muscle Cells
Glucuronidation is a high-capacity pathway for xenobiotic conjugation.
A growing body of evidence has shown that metals (including heavy metals) are able to generate ROS, which subsequently can lead to lipid peroxidation, thereby causing damage to DNA, as well as the consumption and eventual depletion of a cells antioxidant defence mechanisms
