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The Human Microbiome Project, the development of high-throughput technologies, including bioinformatics and metabolomics, recently provided a deeper understanding of the important role of changes in the composition of the gut microbiota and its metabolites in causing AS in humans (105, 106)

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There can be consequent effects upon the compositions of the simple and complex lipids (lipidome) within tissues

In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]