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Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC
By its upstream action of inhibiting lipid peroxidation, GPX4 can indirectly but effectively reduce the expression levels of these destructive enzymes, thereby delaying or preventing ECM breakdown (Xiao et al., 2024) (Figure 1)
Journal of the Renin-Angiotensin-Aldosterone System
The activity of HIF-1 is regulated by oxygen levels, where normoxia promotes HIF-1 degradation and dysfunction while hypoxia ensures its binding to hypoxia response elements, augmenting the transcription of target genes [175]
