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TB-500 research remains at the preclinical stage

10.1016/j.ctim.2017.09.009 42 ChouniA.PaulS
ManducaABaraALarrieuTLassalleOJoffreCLaySet alAmplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits in a mouse model of adolescent and adult dietary polyunsaturated fatty acid imbalance

SREBP-1c promotes fatty acid and TG synthesis, whereas PPAR-alpha facilitates lipid homeostasis by reducing circulating TG and increasing HDL cholesterol levels
