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Biochem J 360:116

These agents have shown promise in preclinical studies for reducing senescent cell burden in aging, fibrosis, and neurodegeneration.53,54 Disruption of the FOXO4-p53 Interaction: While p53 is a tumor suppressor protein that plays a crucial role in cellular stress responses, its prolonged activation in senescent cells contributes to cellular dysfunction.55 Senolytics can modulate the p53 pathway to promote the selective elimination of senescent cells.56 Additionally, the FOXO4 transcription factor can interact with p53 in senescent cells