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Laboratory studies: Early research in animal models showed significant fat-loss effects without adverse metabolic results

However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

Systematic reviews indicate that citrulline can reduce both brachial and aortic systolic pressures in pre-hypertensive individuals, yet inter-patient variability necessitates vigilant monitoring during infusion therapy

Fat Metabolism GH-driven lipolysis studied in metabolic and body composition research models for fat utilisation