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Interestingly, HIF-1 transcription was found to be enhanced upon oxidative stress, resulting in an induction of different sets of HIF-1 target genes in pulmonary artery and vascular smooth muscle cells [79, 80]

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To conclude, our findings indicate that rescuing NRF2 using curcumin may be a targeted therapeutic strategy to both mitigate inflammation and restore tissue repair, and thus prevent inflammatory damage in individuals with cystic fibrosis

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