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Methylation and methyl donor status NNMT consumes methyl donors as part of its enzymatic function

Amino acid metabolism and lifespan regulation Dietary control or supplementation of amino acids has been shown to affect lifespan in various organisms including worms, flies, and mice

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

AOD-9604 works in the body on adipose tissue, also known as body fat tissue