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10.1159/000317434 Dunkel L: Treatment of idiopathic short stature: effects of gonadotropin-releasing hormone analogs, aromatase inhibitors and anabolic steroids

Carbon dioxide, the leaving group, detaches from the beta carbon of isocitrate (C3) and the electrons flow to the ketone oxygen attached to the alpha carbon, granting a negative charge to the associated oxygen atom and forming an alpha-beta unsaturated double bond between carbons 2 and 3

In the M105I system, the reference L75 and Q76 residues interact with the membrane

It naturally occurs in red meat and other animal source foods, but we recommend supplementation to obtain optimal levels of this excellent amino acid