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To integrate these results, we identified genes that exhibited pseudotime-dependent changes during CD4 T cell development and were also differentially expressed in the EV proteomic dataset
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The pattern of repeated cocaine use and subsequent reduction in dopamine can result in the brains reward function becoming completely reliant on cocaine to experience any form of pleasure

Kozarov EV, Dorn BR, Shelburne CE, Dunn WA Jr., Progulske-Fox A
