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In fact, an optimal ratio promotes and increases muscle energy metabolism by reducing the inhibitory effect exerted by the pyruvate dehydrogenase enzyme, which allows the conversion of pyruvate and lactate into acetyl CoA

Most of the time, however, the diagnosis is made late or the disease tends to progress due to its nature
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Their ability to evade conventional treatments, adapt to metabolic stress, and interact with the tumor microenvironment makes them critical targets for innovative therapeutic strategies
