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2 Translational potential of neurotrophic factors MS, especially in the progressive disease phase, poses therapeutic challenge as current disease modifying therapies fail to address the complex crosstalk between glial cells, neurons and CNS-infiltrating cells as well as their highly dynamic functions ( Highlighting the functional dynamics of astrocytes, depletion of reactive astrocytes in early neuroinflammation increased disease severity in EAE, while depletion of reactive astrocytes during the chronic disease phase ameliorated disease pathogenesis (129, 130)

FAQ Should thalassemia patients take vitamin B12 supplements

Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain

Widely-administered questionnaires are (1) the Morningness-Eveningness Questionnaire [57], (2) the Munich Chronotype Questionnaire (MCTQ), and (3) the MCTQ for Shift Workers [58]
