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Acknowledgements The authors thank Nick Rhodes from the Queensland Cyber Infrastructure Foundation (QCIF), Haojing Shao, and Enya Hermsen for their advice on bioinformatical analyses and computational assistance, Alastair McEwan and Mathias Jnsson for their editorial assistance on early drafts of the manuscript, and all members of the Degnan lab for their valuable discussions

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Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g., eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema)

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