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Among the commonly used strains, C57BL/6 mice and Wistar rats are frequently employed [9]

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DPOAE detected ototoxicity in 48% on day 7, 66% on day 14, 70% on day 28, and 77% at day 56 of streptomycin treatment, whereas hearing loss was detected by pure tone audiometry in only 2% on day 7, 11% on day 14, 22% on day 48, and 29% on day 56

In cultured hippocampal neurons, Dihexa treatment for 5 days induced a near 3-fold increase in the number of actin-enriched spines by 41 spines/50m for Dihexa vs