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Chronic hemolysis produces excessive pro-oxidant enzymes, free HbS and heme, which promotes hydroxy radicals accumulation via the Fenton reaction [2], and the retention of mitochondrial ETC activity [73,74,75]

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Overexpression of Nrf2 and CYP2E1 has also been associated with impaired GLUT4 activity and insulin resistance [68]

8 (download XLSX Source data Extended Data Fig
