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Nernst and Brunner incorporated Ficks first law of diffusion and modified the Noyes-Whitneys equation to: where, D = diffusion coefficient ( diffusivity ) of the drug A= surface area of the dissolving solid Kw/o = water/oil partition coefficient of the drug considering the fact that dissolution body fluids are aqueous
Biochem Biophys Res Commun 238(2):387391 Montero J, Morales A, Llacuna L, Lluis JM, Terrones O, Basanez G, Antonsson B, Prieto J, Garcia-Ruiz C, Colell A, Fernandez-Checa JC (2008) Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma
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Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested casecontrol study and meta-analysis
