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While lack of sleep can accentuate them, other contributors such as genetics, ageing, sun exposure, and allergies frequently play a role
"Surgical techniques for quantitative nutrient digestion and absorption studies in the pig." Livestock Science 133.1 (2010): 57-60
Tissue repair processes require water
Overall, results indicate that physical disruption of the disc matrix can lead to focal swelling, GAG loss, disturbed cell-matrix binding, cell clustering, and a degenerative cell phenotype
