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Third, since conditional Slc7a11 knockout mice were unavailable, our in vivo analysis relied on pharmacologic inhibition of the cystine/glutamate transporter and cannot completely exclude off-target effects of sulfasalazine or the contribution of other cell types beyond dendritic cells and fibroblasts in glutathione synthesis

ROS-induced promotion of viral pathogenesis Moderate ROS levels are necessary for numerous cellular functions, including gene expression 58

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In support of this, an animal study has demonstrated that oral administration of diallyl trisulfide at a dosage of 12 mg per day for 13 weeks significantly suppressed the progression of invasive carcinoma and multiplicity of pulmonary metastasis (Singh et al., 2008)