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In rare cases, some people might have severe side effects like: Skin rash, itching, or hives Swelling of the face, lips, or tongue Chest pain or tightness Blue tint to the skin Difficulty breathing or wheezing A swollen, painful area on the leg Dizziness If you experience any of the above side effects, reach out to a healthcare provider immediately

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In the latter process, elevated concentrations of GCs bind their receptors located in the hippocampus, the hypothalamus, and the pituitary gland and reduce further CRH and ACTH production, which limits the activity of the adrenal gland [49]

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