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Patients in the high-risk group exhibited down-regulated immune-effector pathways, elevated expression of the checkpoint molecules PD-L1 and LAG-3, and a trend toward an immune-evasive phenotype, suggesting potential resistance to immunotherapy

These chemicals, which include alkaloids, flavonoids, steroids, coumarins, and terpenoids like eucalyptol, are increasingly recognized for their therapeutic effects, particularly in situations characterized by oxidative stress and chronic inflammation [30]
