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Using H9c2 cardiomyoblasts exposed to high glucose (33 mM), they observed increased ROS, elevated O-GlcNAcylation, and enhanced modification of the pro-apoptotic protein BAD
J Pharm Pharmacol (2013) 65:103743
Notably, excessive acylcarnitine accumulation can further suppress Akt phosphorylation and impair glucose uptake, thereby establishing a vicious cycle that progressively exacerbates insulin resistance [121]
10.1056/nejm198308043090511 120 LangstonJ
