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Another is that randomized trials require sham implants to blind participants
doi: 10.1007/s12263-015-0503-1
Exclusion criteria included subjects who were not able to avoid foods or drinks that contained caffeine within the previous 10 days and during the study period, as well as those with a known history of any gastrointestinal disease such as peptic ulcer, hemorrhoids, gut obstruction, diverticulitis, ulcerative colitis, Crohn's disease, irritable bowel syndrome (IBS), colostomy, recent bowel surgery, and colorectal cancer
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