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Curran, J

Age : Typically younger, active patients (under 50 years) without degenerative joint changes
Direct comparison of the data obtained for the 6 h incubations with itaconate, DI or OI revealed that itaconate in concentrations of up to 300 M did not affect cellular (Fig

9 Importantly, the key enzyme of GSH synthesis, gamma-glutamyl-cysteinyl-synthetase, is already active by the 2nd trimester of pregnancy, suggesting enzymatic immaturity is unlikely to be a primary limiting factor