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In saline-treated animals, Dox caused characteristic myocardial abnormalities, including myofibril thinning, undulation, fractures, and patchy loss of staining affinity
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Nanoparticulate drug delivery systems have shown important advantages in stability and bioavailability, such as: protection of the drug from premature degradation and interaction with the physiological environment increased intracellular penetration increased solubility of insoluble drugs enhanced drug absorption [3] Smaller particles have larger surface area, which improves bioavailability The research has shown that smaller particles, preferably of 100 nm [4], significantly improve the bioavailability of the drug
