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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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Ste 110-106 Dallas, TX 75205 For questions or comments: [email protected] www.IT3-Medical.com Revised January 2016 PIN350-WES/1 Contents: 1 - Cyanocobalamin Injection, USP 1,000 msg/mL (1mL Vial) 2 - Isopropyl Alcohol Pads 1 - Pair of Sterile Surgical Gloves (sterile & latex free) 1 - Adhesive Bandage (sterile & latex free) 1 - BD Syringe (1 mL) w/ Luer-Lok Tip 1 - 22G x 1 BD Precision Glide Needle (draw) 1 - 30G x 1 BD Precision Glide Needle (administer)