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Beyond first-in-human studies, healthy volunteers are also essential in pharmacokinetic (PK) and pharmacodynamic (PD) research

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Recent studies have shown a modulation of synaptic transmission in juvenile GnRH neurons by vitamin D3 and additionally, calcipotriol (a vitamin D analog) hast been shown to act as a neuroprotective agent in neuroblastoma cells ( Furthermore, pharmacogenomics have a relevant impact on the pharmacokinetics and -dynamics of vitamins and influence the effectiveness of any supplementation
