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Lactate secreted by CRC cells promotes the polarization of TAMs toward an M2-like immunosuppressive phenotype, impairs CD8 T cell function, and reduces the efficacy of ICIs [126]

1a), while chronic exposure levels of L2-Cmu were similarly increased to levels expected to provide sufficient coverage in vivo (Supplementary Fig

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
