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Heintz, Sylke Mller, Nicholas J

Safety: Preclinical Signals, No Human Profile FDA acknowledged nonclinical (animal) studies in which BPC-157-related substances appeared to prevent colonic fistulas and hepatic and GI lesions, with hypothesized mechanisms involving up-regulation of growth factors, suppression of inflammatory factors, angiogenesis, and nitric-oxide synthesis

10.7717/peerj.13082 62 LiuW.XuZ.LiH.GuoM.YangT.FengS.et al (2017)

Accordingly, the disadvantage of these models is the absence of a simple way to assess barrier function such as TEER measurement and complicated permeability screening (Cho et al., 2017)