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In an interim analysis of clinical trials, patients were assigned to receive resmetirom (80 mg or 100 mg) or a placebo

By facilitating the entry of fatty acids into mitochondria via the carnitine palmitoyltransferase 1 (CPT1) complex, it stimulates their oxidation and causes a decrease in cell volume

The risk of harm from acetaminophen typically increases with higher doses but can also occur at therapeutic doses, including risks of gastrointestinal bleeding, liver toxicity, kidney failure, and cardiovascular disease (56, 57)

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