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Semaglutide is approved for weight management (Wegovy) and type 2 diabetes (Ozempic/Rybelsus), and although the ESSENCE program provides strong MASH evidence, semaglutide is not yet FDA-approved as a labeled MASH therapy
Science 348 , aaa0698 (2015)
On the other hand, mechanistic studies provide new targets for intervention: loss of BMPR2 signaling in macrophages drives upregulation of pro-inflammatory factors (e.g., CXCL12, C5a) and vascular muscularization (144), while macrophage-derived PDGF-B is a key driver of disease progression (58)
It depends on the injury type
