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123 As CBS and CSE use the same substrates to generate H 2 S, their function is interdependently regulated through substrate/product accumulation/depletion, which will favour one biochemical pathway over the other

Central mechanisms that are involved in these effects are nutrient-sensing pathways, including AMP-activated protein kinase, sirtuins, the target of rapamycin (TOR), and insulin signaling pathways, which collectively coordinate metabolic flexibility and stress adaptation

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Oncogene-induced Nrf2 Transcription Promotes ROS Detoxification and Tumorigenesis