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Nevertheless, it is not an impervious barrier, but rather selectively regulates what passes through the paracellular space
69,73 MMPs not only cleave extracellular matrix substrates but also pre-cursors or active forms of cytokines
In vivo models of autoimmune cystitis have been used to experimentally show that inhibition of TNF- diminishes inflammation within the bladder by disrupting the triggering of mast cells [26,27,28]
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