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Figure 2A clearly demonstrates the use of human artificial chromosome (HAC) vectors to develop Caco-2 cells co-expressing CYP3A4 and CYP450 reductase (CPR) (Takenaka et al., 2017)

Estrogens play an important role in the early development of primary and secondary sexual characteristics
Regulation 1223/2009 and the Cosmetic Products Enforcement Regulations 2013

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