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Avoid compensating by doubling subsequent doses, as this increases side effect risk without recovering the lost metabolic advantage
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Protocols in the 35% range, used once or twice daily over atrisk areas, are based on data showing that AHKCu can influence dermal papilla biology and growthfactor signaling in ways that might be protective
