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[DOI] [PubMed] [Google Scholar] 19.Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP., Jr Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006

[3] Another review of 14 randomized controlled trials also did not consistent evidence of benefit with the use of vitamin B12 supplements, alone or with other B vitamin supplements, on cognitive function in people with either normal or impaired cognition

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Its potential as a safe and specialized treatment agent is highlighted by its capacity to selectively modify fat metabolism without affecting blood sugar levels (1)