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RISK FACTORS CAUSING ENDOTHELIAL DYSFUNCTION Clinically, endothelial dysfunction is characterized by impaired endothelium-dependent vasorelaxation in response to endothelium-dependent agonists such as acetylcholine and bradykinin, or to maneuvers that increase shear stress such as flow-mediated dilatation

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( 10.1111/and.13470) [DOI] [PubMed] [Google Scholar] Zini A, De Lamirande E, Gagnon C.1993

Closing perspectives: Balancing antioxidant activities and redox signaling We now know that in hepatocytes and perhaps in many metazoan cell types, cytosolic disulfide reducing power can come from NADPH via TrxR1, from NADPH via Gsr, or from Met catabolism [107]