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Strategies aimed at restoring tryptophan availability in the tumor microenvironment or inhibiting the immunosuppressive effects of tryptophan metabolites hold great promise for enhancing T cell-mediated antitumor immunity and improving checkpoint immunotherapy
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It is worth noting that in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL, which is under the normal physiologic range
