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TRPC6 actively participates in phototransduction in intrinsically photosensitive RGCs (ipRGCs), but C3 and C7 may have a role in the response mechanism of ipRGCs, a small group of ganglion cells that contain melanopsin and respond to light with depolarization and Ca 2+ influx (Berson, 2007

In summary, gut dysbiosis may contribute to PD pathogenesis through multiple mechanisms, including pathogendriven inflammation, metabolic alterations, immune activation, and enzymemediated proteotoxicity

KEAP1 and done