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The melanin has been deposited in the dermis, the structural layer below the epidermis, often because the original inflammation was more severe or because UV exposure drove the pigment deeper during the healing phase

TACIMA-218: A novel pro-oxidant agent exhibiting selective antitumoral activity
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Distinct roles of the beta1-class integrins at the developing and the mature hippocampal excitatory synapse

doi: 10.1016/j.oooo.2014.12.019 184 LederleWHartensteinBMeidesAKunzelmannHWerbZAngelPet al
