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The VIP (variable importance in projection) score plots based on both PLS-DA (Figure C) and OPLS-DA models (SI, Figure S3C) were then evaluated for screening metabolic features of discriminatory potential and considered as candidate biomarkers

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Since 2D COSY is characterized by very long scanning times, EP-COSI (Echo Planar Correlated Spectroscopic Imaging) and ME-COSI (Multi Echo Correlated Spectroscopic Imaging), were adapted, reducing the scanning time to about 20 min [34]

A meta-omics perspective offers profound implications for understanding the role of gut microbiota in CVD (Xu and Yang, 2021)