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Description
Finally, given the pragmatic nature of the proposed trial, the decision was taken to include consecutive patients seeking medical help at the participating centres, thus ensuring the enrolment of subjects similar to those that would be seen in normal clinical practice

This patient, a man in his forties, was critically ill and partially comatose

This has reduced availability through some channels and may have increased costs

[1] FDA, Warning Letters, available at: (last visited: Sep
