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In contrast, particle radiation, such as protons and carbon ions, has a higher linear energy transfer (LET), resulting in more direct DNA damage and complex cellular lesions that are more difficult to repair

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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

Like CaMKK2, the PKA signalling pathway is also considered to play a key role in the pathogenesis of bipolar disorder, as increased cyclic AMP levels and PKA activity have been frequently observed in post-mortem brains and peripheral cells of bipolar disorder patients [58,59,60,61]